so i found a couple of studies
2 showing it safe,
and 1 (from CHina)saying it is not ,
but it showed an LD50 of 8 to 9grams per Kg
thats about 1/4 ounce for every 2.2 lb. of body weight
you would have to eat... thats a lot. (almost 2lb for a large person if my math is correct)
the study from the NIH said 38grams/Kg of the oil for LD50.
Here is the FDA report, if you have a couple of hours to kill
https://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/ucm403106.pdfSacha Inchi (Plukenetia volubilis L.) powder: acute toxicity, 90 days oral
toxicity study and micronucleus assay in rodents
Conclusions: Sacha Inchi powder did not produce acute toxic effects in rats or mice. The administration of oral doses for 90 days up to 500 mg / kg in rats also did not lead to the appearance of toxicity attributable to the treatment. The product is not genotoxic under the test conditions.
http://jppres.com/jppres/pdf/vol6/jppres17.236_6.1.17.pdfToxicological Evaluation of the Safety of Sacha Inchi (Plukenetia volubilis linneo).
Objective To evaluate the safety of sacha inchi (Plukenetia volubilis linneo) as a health food. Method Acute oral toxicity test, genetic toxicity tests, and rats 30 days feeding test were conducted to evaluate the safety of sacha inchi. Results LD50 of sacha inchi were 7940 mg/kg BW for female mice and 9260 mg/kg BW for male mice. Results of the genetic tests, including the Ames test, bone marrow cells micronucleus assay, and the sperm abnormality test, were negative. Results of the 30 days feeding test showed that sacha inchi had negative effects on the weight gain, food utilization rate, blood count, and serum chemistries. Significant pathological injury in the liver of rats was observed. Conclusion Sacha inchi is toxic under the current experimental conditions.
http://en.cnki.com.cn/Article_en/CJFDTotal-KMYX201407005.htm[Oral toxicity at 60-days of sacha inchi oil (Plukenetia volubilis L.) and linseed (Linum usitatissimum L.), and determination of lethal dose 50 in rodents].
Sacha inchi and linseed oils are harmless at 60 days and present a LD50 above the 37 g/kg of animal.
The notice informs FDA of the view of the notifiers that sacha inchi oil is GRAS, through scientific procedures, for use as an ingredient in bars (such as granola, energy, protein and nutrition bars; use level up to 7%), breakfast cereals (use level up to 6%), condiments and relishes (such as tapenades and hummus; use level up to 7%), chocolates (use level up to 6%), fats and oils (mayonnaise, salad dressings, margarine-like spreads, salad oil; use level up to 17% for mayonnaise, salad dressings, and margarine-like spreads; and, 100% for salad oil), gravies (including meat; use level up to 7%), seed and nut butters (use level up to 7%), and snack foods (use level up to 7%).
https://www.ncbi.nlm.nih.gov/pubmed/21152727
