Hi BonsaiBeast,
We bought a 1/3 acre lot with 37 80+ yr. old trees on it. Our home design was finally ready after 4 attempts to save every tree possible (one drawing even had a tree in the living room). Ultimately we did not have to remove 33 of the trees and have a 3400 sq. ft. home.
Take your time deciding what to build and where the optimum placement and design is. You will be thankful many years from now, as I still am in my wonderful home.
Happy Gardening,
P J, the Dirt Diva