Hi,
i have watched such talks since one or two years ago, and they have curbed my enthusiasm for Annonaceae, but still i may make some remarks which i have also made at the fb group "pawpaw fanatics":
All those experiments with rats were done by injecting the rats with Annonacins, and not feeding them with Annona fruits. (Please correct me if i m mistaken). I never heard of rats being harmed by eating Annonaceae fruit pulp.
Since the time that America was inhabited by humans, Annona fruits have been consumed, some times heavily, but nobody observed any ailment from consuming Annonas pulp. Indians would have observed it. Surely the seeds and skin are toxic, but nature did not intend us to eat the skin or seeds (or leaves as tea, which probably do cause damage).
This site here
https://pfaf.org/user/Plant.aspx?LatinName=Asimina+triloba mentions nothing of danger in eating the pulp. Also it says that the bark is a bitter tonic.
Some people in this forum and in the fb pawpaw group have experience of eating large quantities of pawpaw and other Annonas (i have never eaten too much of them), and the more they eat Annonas the more happy they are, nobody observed any harm.
I personally know a man who has retired early because of Parkinson, but he doesn't know what an Annona kind of fruit is.
Maybe there is a reason to present the pawpaws and other Annonaceae as dangerous? Pawpaws can grow in very cold areas, and many Annonaceae can grow in temperate areas where winter temperatures do not reach below -5 Celsius. At least in Greece, almost nobody knows of Annonaceae fruit, but those who have tasted love them even more than mangos (which are rarely available tree-ripened, and then too expensive). So, if we suppose that people start growing pawpaws and other Annonaceae in countries which import mangos a.o. tropical fruit, will tropical fruit continue to be imported and sold to high prices? (e.g one airborne medium size mango alone costs about 5 euro, while in tropical countries it costs 5 cents). So maybe they want to minimize the consumption of Annonaceae in order to keep the tropical fruit import business as lucrative as it is now. I don't say that the research on Annonacins is fake news, but it may have been conducted and presented in such a way as to serve certain interests rather than the people's health.