To my knowledge, no. Gypsum is used to ameliorate salt burn, and you want the Ca to K ratio to be above 10 to 1 (probably preferably 20 to 1) for best brix.
There is an FSHS article that I posted here in another thread a while back where growers applied multiple tons of gypsum per mango tree (like 4k pounds per tree if memory serves), and the outcome was very favorable.
So, the only detriment would be a slimmer wallet if you apply more than needed.
I apply it once a year usually.
Update: here's the fshs article; looks like it was 1k pounds of gypsum per tree per year:
https://fshs.org/proceedings-o/1962-vol-75/364-371%20(YOUNG).pdfIs it possible to overdo the gypsum? Im trying to decide how much to buy. You use it once a year or multiple times?
Got a big list of stuff on order for January with Harrells. They have the polyon slow release 16-6-12 50lbs for 35$. Its basically the same stuff as osmocote. Also they have water soluables for cheap. Can't beat the prices. You guys probably have a Harrell's out there. They have a wharehouse here, I put the order in to my rep via email and show up and they load the truck.