Grasping at straws here -- any chance it could be sunburn? Heavily pruned trees can sunburn if not provided with shade.
The cuban may beetle literally killed my pace
. They would defoliate it completely and then devour the newly emerging foliage. (Younger trees can't normally take two complete foliage losses in succession.) That was the only mamey that was close to the property line (neighbors have grass and hence loads of cuban may beetle grubs). All the others, which are away from the prop line, are doing great.
I think my "pantin" is actually a viejo, which as it turns out is an absolutely awesome mamey -- small-statured, strong bearer, very precocious, and quite good. Pantin has an edge in terms of flavor, but as you've pointed out, they are really finicky! I've lost 2 so far, one after a week of heavy rains (in well drained soil no less) and the other due to cuban may beetles. I've talked to others who've expressed the same sentiment about the pace.
If you're having problems with mamey not holding fruit, it's very likely a nutritional issue. Try giving it a good fertilizer with nitrogen. The 8-2-12 that Truly Tropical carries is magic.