Actually, smokeless tobacco is less cancer-risk than smoking. The main carcinogens still in it are nitrosamines; the nitrosamine level directly correlates with the cancer risk.
Annonacin is in every part of annonas. I say this as someone who lives and still eats annonas (just in moderation). It's important to realize that just because something is natural doesn't mean that it's healthy or safe, or because something is artificial it's bad. Insecticidal soaps are artificial. Rotenone is natural. Which pesticide would you rather eat?
I don't think anyone is arguing this part of your statement. It's well known that hundreds of plants are poisonous, and even lethal. Socrates was sentenced to death by drinking of hemlock. So what you are saying was well known thousands of years ago. As for the part of your statement about artificial products, what i'm saying is that most artificial products, like imidacloprid, are NOT properly tested long term. When you eat them you are taking a HUGE risk...rolling the dice. You don't know and most don't know if they are really safe.
Oscar,
What you also have to realize is that exactly the same is true for bioactive plant products. No one has studied them, and should you contract some sort of illness, it cannot be said if your diet was or was not at fault. The annonacin issue is a perfect case in point, it took a group of scientists to look at the problem and determine that the soursop tea was the culprit.
I am not saying that we should soak our fruit trees in anything and everything that comes along, but people need to realize that the mantra "natural = good, synthetic = bad" is simply ridiculous.
To address the OPs original question, I will say that I am using imidacloprid drenches on my young citrus since they were getting too heavily damaged by leaf miners otherwise. But I do not plan on any fruit harvests for at least two years. Once they get to bearing age I will leave them alone and let the bugs "have their share." This is not because I am really worried about any long term toxicity, but rather because I believe that it is a better way to farm.
Richard