It's very true that we should sometimes try for a cross despite the odds. However:
1) I regard nucellar reproduction as like a cancer for a species. I really want to eliminate it whenever possible.
2) I don't have enough space or resources to start hundreds, or even dozens, of seedlings in search of a successful cross.
3) Except for parent plants that have clear and obvious physical traits (like trifoliata's three-lobed leaves), I can't distinguish crosses from non-crosses.
Still, I plan on making some implausible attempts just to see what I get. ('Moro' Blood orange x 'Nagami' Kumquat = Bloodquat?)