Variety selection is very important here in Florida. Growing something like a Brandywine is going to be difficult because it is not very disese resistant. It could be done if you sprayed fungicide every week, but few people want to do that. Most little tomatoes like Grape, Cherry, and Campari work well as long as you spray with BT (for caterpillars) every once in a while. I like the multi color grape and cherry types especially. The larger slicing tomatoes are a little harder. However, I had good success with Homestead last year. The only knock I have against it is that it is determinate (I prefer indeterminate tomatoes that keep producing over time). Also, keep in mind that big tomatoes require lots of calcium to keep them from getting blossom end rot.