Really depends on where in SC. Its a very variable area. I am from Coastal Ga and grew up on an island not far from the SC border, in winter I used to duck hunt on the Savannah river, which is the border. If you are talking on the coast, as in, you are living in the barrier island areas, not just living near I-95 then you can expect to grow some sub tropicals and have pretty good luck with citrus. The island I grew up on is about 20 minutes by boat from the Atlantic and I am always jealous of how healthy and lush their citrus trees are there compared to what I can grow here in FL. Plus the added bonus of pecans growing insanely well, talking huge 75' tall trees that drop tons of nuts in the fall. Loquats grow very well and I know the island my parents still live on has them everywhere growing wild.
The negative is winters are very unrpedictable. You will get freezes, some winters will drop into the teens for a day or two. We even had snow sit on the ground 3 days in 89 with some of the shaded areas lasting longer. It doesnt get that cold with the weather cycles changing very often but the potential is there. I would still expect to see upper 20s and 30s every year for at least a couple days.
Inland away from the Ocean water gets colder quickly. Remember Snowmageddon? Chic-Fil-A coming in during a blizzard and its employee volunteering to walk down the highways handing out warm sandwiches to people trapped in traffic jams in the snow for several days? That was in GA. While that was a bad one, they get lesser forms of it every other year or so. I dont hear much out of SC but I can only imagine they would get it too being the next state up. The farther west you go the higher elevation and the colder it would probably get. So you could probably get away with more stone fruit but less subtropicals.
So in short, if you are right on the coast your options for sub tropicals are much higher than if you live in the western end of the state. Note there is also a shift in soil content as well once you hit a certain point going west. But with prep and protection your options are always there. Theres a dude in Evansville Indiana with palm trees in his front yard, blew my mind when I saw them in winter, so it can be done.