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It is possible, I graft pear trees on mespilus germanica very well. But some varieties are more compatible.Pear trees are compatible with: mespilus germanica, cydonia, crataegus ( monogyna ) etc.However, in general, one should avoid grafting a deciduous fruit tree onto an evergreen fruit tree
No, unless the variety (loquat) is not temperature resistant enough for you. Otherwise, it's not a problem, you can graft evergreen citrus trees onto the poncirus tree. So you see this example shows that it is not a problem.