I purchased a Meiwa some years ago, it went ok for a while, then the graft died. The rootstock turned out to be sweet orange, which grew back well. Probably incompatible.
Also similar situation with F . hindsii and Calamondin on Swingle, both did ok for 4 years, then scion died.
Never seen C 22 bitters here, but hopefully this info may also help ??
C 22 bitters is not exactly a Swingle sibling, as Sunki mandarin is one of the other parents.