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Citrus General Discussion / Re: Q And A: Why Does Grapefruit Affect Statins (Cholesterol Lowering Drugs)?
« on: December 04, 2020, 01:12:51 AM »
It inhibits CYP3A4, a cytochrome P450 enzyme produced by the liver, which is responsible for metabolizing many drugs. This can increase the blood concentration of the drug. For some drugs, this can increase the concentration to toxic levels. The same thing can happen if you take multiple drugs that are metabolized by the same P450 enzyme because the metabolic effects can be saturated. Talk to your doctor about the possibility of reducing your dose when you are consuming grapefruit.